In the Middle Ages, Opuzen was known as Posrednica.
The center of the old part of Opuzen is a classic Roman Forum.
He worked as a doctor in Imotski and Opuzen.
He won the Opuzen City Prize for the promotion of music and education.
The partisan war hero, Stjepan Filipovi, was born in Opuzen in 1916.
The road also provides connection to D62 state road and cities of Metkovi and Opuzen.
The Republic of Ragusa in the 14th century had major trading markets ( mainly trading in salt ) in Opuzen.
Croatian section of the highway is officially named Split, Opuzen and Dubrovnik to the border with Montenegro at Karasovii.
Important cultural and sport events related to Opuzen and the local countryside are " The Melodies of the Croatian South " and " Opuzen Boat Marathon ".